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Enzyme-Active Retinol Serum

Enzyme-Active Retinol Serum

Rated 4.9 out of 5
Based on 188 reviews

60-day treatment, 30ml/1oz

An entire skin-transforming routine in a single bottle.

This award-winning serum captures the most gentle and effective form retinol on Earth (retinal)––estimated by dermatologists to be 20x more effective than regular retinol. This elusive ingredient is captured using Protocol's patented oxygen-free bottling technology, designed by the Protocol Lab Team in collaboration with aerospace engineers.

Most clients see improvements within 10 days.

Formulation and active ingredient found to be more effective at reversing wrinkles and dark spots than a $5,000 glycolic acid chemical peel applied in a clinical setting.*

Key Active: 0.1% retinal, the enzyme-calibrated form of retinol

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All products are vegan, cruelty free and 100% recyclable through our Emptiez Recycling Program.

*C. Rouvrais. Journal of Cosmetic Dermatology 2018 Dec;17(6):1136-1143

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How to Use

Apply one pump at night after cleansing or rinsing with water while skin is still damp. Beginning users should wait a few minutes or until dry before following up with evening moisturizer. Advanced users can wait up to 30 minutes before applying moisturizer to maximize potency. This product is compatible with other toners or actives, however, as a general practice our lab team recommends a simple cleanser, active, moisturizer routine for all skin types. Our clients often find that this serum allows them to remove several steps from their routine with better results.

For further details, don't forget to check out our blog.

Ingredients

Aloe Barbadensis Leaf Juice, Water, Niacinamide, Cyclodextrin, Caprylic/Capric Triglyceride, Gluconolactone, Carnitine (L), Glycerin, Polysorbate 20, Enzyme-Active Retinol/Retinal/Retinaldehyde, Phenylethyl Resorcinol, Bisabolol (L-alpha), Tocopheryl Acetate (D-alpha), Lonicera Japonica Flower Extract, Lonicera Caprifolium Flower Extract, Sodium Lactate, Lecithin, Ethanol, Pentylene Glycol, Maltodextrin, Xanthan Gum, Sodium Benzoate

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"This is simply the most advanced and effective non-prescription retinol serum on the market."

- Board Certified Dermatologist, Dr. Jen Haley

Clinically proven

Nature's most powerful and gentle renewing ingredient. Finally captured in a bottle.

There are A LOT of ingredients that can technically be called "retinol" in skincare products (retinyl palmitate, hydroxypinacolone retinoate, retinaldehyde, retinol retinoate,...and on and on).

However, only one form has been clinically measured to reduce wrinkle depth within weeks...and without drying or irritation. This form, which we call Enzyme-Active Retinol (more commonly known as "retinal" with an "a"), is the form that is naturally created by your skin when you apply regular retinol (Vitamin A) to it. By applying this super-bioavailable form directly, you save your skin the irritation of converting it and instead get just pure, renewing power.

Little orange bottle

LITTLE ORANGE INGREDIENT FORTRESS

Super potent ingredients require aerospace-grade packaging.

This rare, unique form of retinol is extremely delicate and needs to be made and bottled in a 100% oxygen-free and UV-free environment. Protocol's lab team uses patented containment technology that was designed for the nuclear and aerospace industry to ensure each serum is made without exposure to a single oxygen molecule or ray of light.

The secret that brings it all together though, is what we call our Little Orange Ingredient Fortress. Our clinical-grade, totally airless and UV-proof bottle is built like the space shuttle to protect our super potent ingredients to the last drop. The quality of product it delivers will be apparent from the first pump.

Microscopic "before and afters" are our favorite before and afters.

If a skincare company doesn't show you proof on the cellular level, it means they don't have it.

These microscoptic photos show the thickness of the outer, collagen-filled layer of your skin.

When that layer ages, it deteriorates creating wrinkles, dryness and dull skin tone. When you apply clinical-grade retinol, it jumpstarts dozens of cellular processes in your skin to thicken your skin layers with healthy collagen and elastin for plump, hydrated, wrinkle-free skin. And we're not talking about some hopeful date in the future. This process can show visible changes to your skin within days.

FAQs

When should I use the retinol serum?

The best time to use the Enzyme-Active Retinol Serum is in the evening, but you can use it in the daytime if that suits your routine better. It makes the most sense to apply our retinol serum in the evening to help your skin self-repair as you sleep without being exposed to oxidative damage. Plus, this gives you room in the daytime to use our protective Vitamin C Superserum.

Is this retinol serum safe if I have rosacea or eczema?

The Enzyme-Active Retinol Serum is appropriate for all skin types, and it’s not known to cause any issues for clients with eczema or rosacea. In fact, our clients with either condition report seeing great results! Note that this isn’t intended as medical advice. If you think you might be suffering from any skin or health conditions, speak to your doctor about appropriate treatment.

Can I use retinol everyday?

Yes, Most people can use retinol every day! However, everyone's skin is different. If you have never used retinol before you may choose to ease into use by only applying every other day before transition to daily application. You can also mix it with your moisturizer the first few weeks in order to reduce the absorption rate. Once you are ready, we recommend applying retinol at night, letting it sit for 5 to 30 minutes do allow for absorption and then applying a hydrating moisturizer.

What is the percentage of retinol in the Enzyme-Active Retinol Serum?

The Enzyme-Active Retinol Serum contains 0.1% retinal, which is estimated to be 20 times stronger than retinol. Studies show that at 0.05% to 0.1%, retinaldehyde can effectively reduce skin roughness and signs of aging without irritating the skin.

What does retinol serum do?

Retinol acts like a super nutrient for your skin cells. It boosts dozens of important renewing processes in your skin to visibly fill in wrinkles and fine lines, fades dark spots and encourages natural collagen production. Overall, you'll see smoother, more even, and youthful-looking skin! Our Enzyme-Active Retinol Serum includes the only form of retinol that is clinically measured to reduce wrinkle depth within 14 days, without irritating your skin.

At what age should I use retinol?

Different age groups use retinol for different purposes. Younger clients or clients who still struggle with breakouts use retinol for breakout control and skin clarifying. Clients who are seeing signs of aging (at any age) use retinol to reverse signs of aging as well as to prevent aging signs from forming! If you see no visible signs of aging, we recommend focusing on the daily application of Vitamin C Serum and the once-annual application of retinol. After your first visible signs of aging, we recommend daily use of retinol as well.

Are there any ingredients I should avoid using with retinol?

You don’t need to avoid anything specific while using retinol, but you’ll want to introduce new products carefully and watch out for signs of irritation or over-exfoliation, such as redness, tightness, or flaking. There is a lot of outdated information out there suggesting that you shouldn’t combine retinol with certain ingredients when, in reality, combining retinoids with AHAs, vitamin C, niacinamide, or benzoyl peroxide often leads to better results. To maximize the efficacy of your retinol, we recommend using it at night before any other leave-on products.

Customer Reviews

average rating 4.9 out of 5
Based on 188 reviews
  • 5 Stars
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97% of reviewers would recommend this product to a friend
Customer photos and videos
188 Reviews
Reviewed by Kimberly
Verified Reviewer
I recommend this product
Age
35 - 44
Skin Type
Combination
Skin Concerns
  • Acne
  • Age Defense
  • Dark Spots
  • Pores
My Results
  • Brighter Complexion
  • Glowing Skin
  • More Even Tone
  • Reduced Sun Spots/Discoloration
Rated 5 out of 5
Review posted

My 10 year old acne scars literally fell off my face

I thought I was imagining it at first but 3 weeks in my whole family was commenting on how good my skin looked and asking what I was doing. I took before pic a few days in because it already seemed to be changing so quickly. The after pics are from my 2nd round of the complete line and the improvement is REAL. I'm shook. THANK YOU PROTOCOL!!

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Reviewed by connie l.
Verified Buyer
I recommend this product
Rated 5 out of 5
Review posted

I love the moisturizer

I am 68 years young and just coming off chemo and radiation treatments which is so hard on your skin. I have been using Protocol for just over 3weeks and really can tell a difference.

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Reviewed by Julia B.
Verified Reviewer
I recommend this product
Age
35 - 44
Skin Type
Dry
Skin Concerns
  • Age Defense
  • Dark Spots
  • Wrinkles & Fine Lines
My Results
  • Glowing Skin
  • Brighter Complexion
  • Firm & Lifted Skin
  • Reduced Age Signs
  • More Even Tone
Rated 5 out of 5
Review posted

Superior retinol!

I’m on my 3rd bottle of this product— I never write reviews but I’m a huge fan of this retinol! As a licensed esthetician, I understand the great importance of this ingredient in a balanced regimen and have tried MANY products, often with high price-points. This is the best BY FAR. I experienced no “purge,” no sensitivity, and almost immediate results. This retinol is the unsung hero of the market. If you’ve have negative experiences with retinol in the past, don’t give up until you’ve tried this one. 🙏🏻

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Reviewed by Kaitlyn
Verified Buyer
I recommend this product
Age
25 - 34
Skin Type
Dry
Skin Concerns
  • Acne
  • Age Defense
  • Dark Spots
  • Dryness
  • Dullness
My Results
  • Healthy Skin
  • Glowing Skin
  • Smoother Skin
  • Firm & Lifted Skin
  • Softer Skin
Rated 5 out of 5
Review posted

The Only Retinol

I've used Protocol's Enzyme-Active Retinol Serum for two years with great results. My skin has looked amazing and healthy. Just to switch things up, I decided to give Tretinoin a try. I used Tretinoin prescribed by my dermatologist for 6 months and went through the expected purging stage followed by the glowing -skin stage. However, even after the purging stage, my skin just wasn't nearly as good as it had been while using the Enzyme-Active Retinol Serum. I stopped Tretinoin and used the Enzyme-Active Retinol Serum for two nights and to my complete shock (by the speed and the difference in my skin), my skin went right back to being as smooth, hydrated, and dewy as it was pre-Tretinoin. I'm convinced - this is the ONLY retinol!

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Reviewed by Rada D.
Verified Buyer
I recommend this product
Age
35 - 44
Skin Type
Combination
Skin Concerns
  • Acne
  • Dullness
  • Pores
  • Dark Spots
  • Age Defense
My Results
  • Glowing Skin
  • Smoother Skin
  • Skin Radiance
  • Reduced Sun Spots/Discoloration
  • More Even Tone
Rated 5 out of 5
Review posted

Best retinol serum out there!

This serum is amazing! It does exactly what it says - brings you all the benefits of the retilnol, withoit any irritation.

I initially was deciding between this and Medik8 Christal Retinal. I decided to go with Protocol as the ingredients list was a lot shorter, which really appealed to me. I am really happy with my decision.

This serum is very lightweight, does not irritate, cause rednessnor any dryness at all. All you get is amazing glow, smoother skin and more even tone. It also helps with reducing the old acne scars and keeping blemishes at bay. And you don't need to wait long until you see results. I noticed a difference after 2 days!

I really hope this product will never be discontinued, as it is my holy grail!

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