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Enzyme-Active Retinol Serum
+ Limited FREE Gift

(Formerly Oxidated Retinol™ Serum)

Rated 4.8 out of 5
Based on 124 reviews
Enzyme-Active Retinol Serum + FREE Treatment Product
Enzyme-Active Retinol Serum + FREE Treatment Product
Enzyme-Active Retinol Serum + FREE Treatment Product
Enzyme-Active Retinol Serum + FREE Treatment Product
Enzyme-Active Retinol Serum + FREE Treatment Product
Enzyme-Active Retinol Serum + FREE Treatment Product
Enzyme-Active Retinol Serum + FREE Treatment Product
Enzyme-Active Retinol Serum + FREE Treatment Product
Enzyme-Active Retinol Serum + FREE Treatment Product
Enzyme-Active Retinol Serum + FREE Treatment Product
Enzyme-Active Retinol Serum + FREE Treatment Product
Enzyme-Active Retinol Serum + FREE Treatment Product

30 ml / 1 fl oz | 60 days | $88

NEW CLIENT PROMOTIONAL INCENTIVE ––
Choose a free gift:

"Simply the most advanced and effective non-prescription retinol serum on the market."

–Dr. M. Itkonen, USC Cosm. Dermatology 

CLINICAL INDICATION:

CLINICAL INDICATION:

Wrinkles & fine lines, hyperpigmentation, unevenness, blemish control, general age defense

EXPECTED RESULTS:

EXPECTED RESULTS:

Visibly smoother, more even and youthful-looking skin.

THERAPEUTIC ACTIVE:

THERAPEUTIC ACTIVE:

0.1% retinal, the enzyme-calibrated form of retinol

(Estimated 20x more effective than regular retinol) 

Free gift promotion is not eligible for additional discounts, including #NEWCLIENT code.

Designed in Los Angeles by an obsessive team of chemists and doctors.  

92% see improvements to their skin's smoothness and/or evenness within 14 days.

The Science:

There are A LOT of ingredients that can technically be called "retinol" in skincare products (retinyl palmitate, hydroxypinacolone retinoate, retinaldehyde, retinol retinoate,...and on and on). 

However, only one form has been clinically measured to reduce wrinkle depth within weeks...and without drying or irriation. This form, which we call Enzyme-Active Retinol (more commonly known as "retinal" with an "a"), is the form that is naturally created by your skin when you apply regular retinol (Vitamin A) to it. By applying this super-bioavailable form directly, you save your skin the irritation of converting it and instead get just pure, renewing power.

Why is no one else doing this?

This form of retinol is extremely fragile and needs to be made and bottled in a 100% oxygen and UV-free environment.  Protocol's lab team uses patented containment technology that was designed for the nuclear and aerospace industry to ensure each serum is made without exposure to a single oxygen molecule or ray of light.

The secret that brings it all together though, is what we call our Little Orange Ingredient Fortress:

Our clinical-grade, totally airless and UV-proof bottle that's built like the space shuttle to protect our advanced and fragile ingredients. The quality of product it delivers will be apparent from the first pump.

Improved skin in 60 days guaranteed. 


Clients typically notice improvements to complexion tone and evenness almost immediately. Fine lines such as crow's feet are often visibly reduced or completely reversed within weeks of use, while deeper wrinkles such as those on the forehead may require ongoing treatment. We recommend using the 60-day regimen continuously, but using 2-3 times per year will also maintain baseline results. 


As with all topical products, we recommend all women who are pregnant or nursing speak with their physician before purchasing.

average rating 4.8 out of 5
Based on 124 reviews
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98% of reviewers would recommend this product to a friend
Customer photos and videos
124 Reviews
Reviewed by Kate
Verified Buyer
I recommend this product
Rated 5 out of 5
Review posted

I can't believe it

This is unbelievable. I'm 32. I've been using retinol products and Retin-A 0.05 for about 6 years. I microneedle and get red light therapy. This is the best retinol I have ever used. I've seen more results from one week of use than I have from months of Retin-A. I can also use it every night without drying which is insane. I'll report back in 6 months but this is not a drill. It is. The best.

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Reviewed by Erika
Verified Buyer
I recommend this product
Rated 5 out of 5
Review posted

CLEAN, PRISTINE, & INTELLIGENT SKINCARE

I cant even express to you how much I’ve battled with hormonal cystic acne, dark hyperpigmentation, dry, and oily skin. I’ve spent thousands on peels, creams, serums, pills, and countless sad evenings researching ingredients and how they can alter your skin and gut microbiome. Through the years I’ve had to learn the hard way how paramount clean and well preserved ingredients are. After 13 years of an arduous journey- I’ve landed, with confidence, on Protocol. As we all know, Vitamin C is a cute but unstable monster, retinol is an irritating acid at certain percentages, HA is tricky without the right moisture/reactive combination but Protocol has mastered all of it with scientific sophistication. Aside from its CLEAN (non carcinogenic, paraben free, hormone-disrupter free) ingredients, the packages are ingenious (check out their page on the way no light or air penetrate the serums). Also, their customer care is the sweetest, most understanding, and most responsive I’ve dealt with.

Listen, I don’t usually freak like this over a brand but I’m telling you it will change your life and simplify your complicated skin routine. I look younger, I look fresher, I look brighter, and I feel like I can just take a breath and trust this brand. You owe it to yourself to try this. My skin made me sad for so long and with this I’m getting my confidence back every day.

XX

Erika

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Reviewed by Kirby O.
Verified Buyer
I recommend this product
Rated 5 out of 5
Review posted

Fan for life.

I've had issues with my skin for the past two or so years, I think because of damage done to my skin barrier from using Biologique Recherche p50, and then other chemical exfoliants. My skin was very, very angry with me, and I responded with panic and more products. Wrong. I finally gave my skin some space to breath (thank you stay-at-home orders), and didn't put anything besides sunscreen on for two weeks - highly recommend. The first products I used again were Protocol and Avène Cicalfate+ Restorative Protective Cream (so good for sensitive skin), and my skin has never looked better. Like ever.

I have never seen these types of results, yet alone this quickly (about three months with Retinol/Vit C/Moisturizer). I use the Retinol every second or third night so I don't have bitchy skin deja-vu. The cleanser is magic, truly. So worth it. I just started using it, and every other night works best so far. I think I started out putting too much of the moisturizer on (I feel like this might have been part of my problem all along), but now that I take more time to apply instead of just slapping it on I am much happier with how my skin really absorbs the product. I use it during the daytime, and Cicalfate at night. My skin is completely different now - blemish free, less redness, super plump and strong, and I worry far less about it (the best part).

Protocol's customer service is also fantastic in general, they get that it's 2020 and they're a skincare brand. Thank you!!

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Reviewed by Sam
Verified Buyer
I recommend this product
Rated 5 out of 5
Review posted

WOW

This is hands-down the best retinol and moisturizer I have ever used - that is compared to countless other brands (Drunk Elephant...almost all of the major clean retinol brands on the market). I experienced no drying or skin sensitivity from the retinol - it took 2 weeks to start to see a difference for me. The simple moisturizer itself is a game-changing product for me -- I gave up moisturizers in favor of oils 6 + years ago because they usually feel heavy, drying, or cause acne on my skin -- not this one. I am grateful it was included with the retinol, or I would not have tried it. All-around, my skin is GLOWING. My skin has not looked this good in a long time. Even my husband has noticed (which is rare). Given I have sensitive, dry, acne-prone skin -- I imagine this will work well for others too. These products are incredible.

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Reviewed by Megan H., from United States
Verified Buyer
I recommend this product
Rated 5 out of 5
Review posted

I'm obsessed!

Best retinol I have ever used! I have used almost all the retinol products through Sephora (I am Rouge status at Sephora because I spend way too much money there) and was not satisfied with many of the high priced brands. This retinol actually made my skin do the "retinol purging" where it got worse to shed all the impurities and now I have clear and soft skin. This made me know this stuff actually works. I am still on the fence about the cleanser and moisturizer- I know they both work well, but so do some of my other favorite brands. I will absolutely buy both serums again individually.

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