"Simply the most advanced and effective non-prescription retinol serum on the market."

The most effective and gentle, renewing molecule on Earth
Captured in a bottle for the first time ever.
Retinal (with an "a") is the precursor to retinoic acid - the prescription form of retinol and the only form of retinol your skin can actually use to boost its renewing activity. Every form of retinol needs to be converted into retinoic acid by your skin before it can be put to use. However 90% of retinol serums on the market use forms of retinol that are too difficult for your skin to convert.


Smoother & youthful-looking skin

Fills in wrinkles & fine lines

Fades dark spots and boosts collagen
Don't take our word for it
There are A LOT of ingredients that can technically be called "retinol" in skincare products (retinyl palmitate, hydroxypinacolone retinoate, retinaldehyde, retinol retinoate,...and on and on).
However, only one form has been clinically measured to reduce wrinkle depth within weeks...and without drying or irritation. This form, which we call Enzyme-Active Retinol (more commonly known as "retinal" with an "a"), is the form that is naturally created by your skin when you apply regular retinol (Vitamin A) to it. By applying this super-bioavailable form directly, you save your skin the irritation of converting it and instead get just pure, renewing power.


Enzyme-Active Retinol Serum
92% see improvements to their skin's smoothness and/or evenness within 14 days.


This form of retinol is extremely fragile and needs to be made and bottled in a 100% oxygen and UV-free environment. Protocol's lab team uses patented containment technology that was designed for the nuclear and aerospace industry to ensure each serum is made without exposure to a single oxygen molecule or ray of light.
The secret that brings it all together though, is what we call our Little Orange Ingredient Fortress.
Our clinical-grade, totally airless and UV-proof bottle that's built like the space shuttle to protect our advanced and fragile ingredients. The quality of product it delivers will be apparent from the first pump.

complexion tone & evenness
Visible improvements guaranteed in 60 days
Clients typically notice improvements to complexion tone and evenness almost immediately. Fine lines such as crow's feet are often visibly reduced or completely reversed within weeks of use, while deeper wrinkles such as those on the forehead may require ongoing treatment. We recommend using the 60-day regimen continuously, but using 2-3 times per year will also maintain baseline results.
As with all topical products, we recommend all women who are pregnant or nursing speak with their physician before purchasing.
Clients are encouraged to document their skin's progress using the Setlist App.